ms data filtration and extraction software Search Results


data base hmdb web tool  (Human Metabolome Technologies America)
86
Human Metabolome Technologies America data base hmdb web tool
A Workflow of untargeted metabolomics upon EXT2 knockdown in irradiated DD-T4 and U-251MG cells. B Differential impact of the treatment groups on the metabolome of DD-T4 and U-251MG GBM models determined by Partial Least-Squares Discriminant Analysis (PLSDA) using MetaboAnalyst.ca web tool. C Filtration of LC-MS/MS analytical features for metabolite identification using Human Metabolome Data Base <t>(HMDB)</t> web tool. D Categorization of metabolite content by <t>HMDB</t> and determination of changes in metabolite abundance upon EXT2 depletion and irradiation. Numbers in column graph indicate significantly altered metabolites in the respective color-coded metabolite category. Data are visualized as mean ( n = 4) of the fold change (relative to siC/IR). Significant alterations were determined by t -test with p < 0.05. E Identified deregulated metabolic pathways upon EXT2 knockdown and irradiation obtained from KEGG and Small Molecule Pathway Database (SMPDB) database analyses. The impact is quantified as a percentage of significant up- and down-regulated metabolites. F Overlap of significantly altered metabolites, shown in D in DD-T4 and U-251MG models. G SAM metabolite abundance in unirradiated and irradiated EXT2-depleted cell cultures. H Mapping of metabolites involved in SAM metabolism altered upon EXT2 knockdown identified from untargeted metabolomics. Color code: red, upregulated; blue, down-regulated; green, not changed; black, metabolite not found. Metabolite abundance indicates peak intensity value ( n = 4; one-way ANOVA; ** p < 0.01; *** p < 0.005).
Data Base Hmdb Web Tool, supplied by Human Metabolome Technologies America, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ms+data+filtration+and+extraction+software/base+data+hmdb+tool+web/pmc12432244-94-12-10
Average 86 stars, based on 1 article reviews
data base hmdb web tool - by Bioz Stars, 2026-10
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(ko validated) msh2 polyclonal antibody  (Elabscience Biotechnology)
N/A
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in
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(ko validated) pms2 polyclonal antibody  (Elabscience Biotechnology)
N/A
The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination.
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Image Search Results


A Workflow of untargeted metabolomics upon EXT2 knockdown in irradiated DD-T4 and U-251MG cells. B Differential impact of the treatment groups on the metabolome of DD-T4 and U-251MG GBM models determined by Partial Least-Squares Discriminant Analysis (PLSDA) using MetaboAnalyst.ca web tool. C Filtration of LC-MS/MS analytical features for metabolite identification using Human Metabolome Data Base (HMDB) web tool. D Categorization of metabolite content by HMDB and determination of changes in metabolite abundance upon EXT2 depletion and irradiation. Numbers in column graph indicate significantly altered metabolites in the respective color-coded metabolite category. Data are visualized as mean ( n = 4) of the fold change (relative to siC/IR). Significant alterations were determined by t -test with p < 0.05. E Identified deregulated metabolic pathways upon EXT2 knockdown and irradiation obtained from KEGG and Small Molecule Pathway Database (SMPDB) database analyses. The impact is quantified as a percentage of significant up- and down-regulated metabolites. F Overlap of significantly altered metabolites, shown in D in DD-T4 and U-251MG models. G SAM metabolite abundance in unirradiated and irradiated EXT2-depleted cell cultures. H Mapping of metabolites involved in SAM metabolism altered upon EXT2 knockdown identified from untargeted metabolomics. Color code: red, upregulated; blue, down-regulated; green, not changed; black, metabolite not found. Metabolite abundance indicates peak intensity value ( n = 4; one-way ANOVA; ** p < 0.01; *** p < 0.005).

Journal: Cell Death and Differentiation

Article Title: A novel role of exostosin glycosyltransferase 2 (EXT2) in glioblastoma cell metabolism, radiosensitivity and ferroptosis

doi: 10.1038/s41418-025-01503-w

Figure Lengend Snippet: A Workflow of untargeted metabolomics upon EXT2 knockdown in irradiated DD-T4 and U-251MG cells. B Differential impact of the treatment groups on the metabolome of DD-T4 and U-251MG GBM models determined by Partial Least-Squares Discriminant Analysis (PLSDA) using MetaboAnalyst.ca web tool. C Filtration of LC-MS/MS analytical features for metabolite identification using Human Metabolome Data Base (HMDB) web tool. D Categorization of metabolite content by HMDB and determination of changes in metabolite abundance upon EXT2 depletion and irradiation. Numbers in column graph indicate significantly altered metabolites in the respective color-coded metabolite category. Data are visualized as mean ( n = 4) of the fold change (relative to siC/IR). Significant alterations were determined by t -test with p < 0.05. E Identified deregulated metabolic pathways upon EXT2 knockdown and irradiation obtained from KEGG and Small Molecule Pathway Database (SMPDB) database analyses. The impact is quantified as a percentage of significant up- and down-regulated metabolites. F Overlap of significantly altered metabolites, shown in D in DD-T4 and U-251MG models. G SAM metabolite abundance in unirradiated and irradiated EXT2-depleted cell cultures. H Mapping of metabolites involved in SAM metabolism altered upon EXT2 knockdown identified from untargeted metabolomics. Color code: red, upregulated; blue, down-regulated; green, not changed; black, metabolite not found. Metabolite abundance indicates peak intensity value ( n = 4; one-way ANOVA; ** p < 0.01; *** p < 0.005).

Article Snippet: C Filtration of LC-MS/MS analytical features for metabolite identification using Human Metabolome Data Base (HMDB) web tool.

Techniques: Knockdown, Irradiation, Filtration, Liquid Chromatography with Mass Spectroscopy